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Development of a multi-component drug from turmeric using central composite design

Xiaohang ZHANG,Shengnan HAN,Yan LI,Jianlan JIANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3,   Pages 362-368 doi: 10.1007/s11705-014-1439-5

Abstract: components from the traditional Chinese medicine turmeric were chosen for use in a multi-component antitumor drugquantitative composition-activity relationships in order to optimize the amount of each component in the drug

Keywords： multi-component drug development     central composite design     turmeric     curcuminoids    

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Engineered T Cell Therapies from a Drug Development Viewpoint Review

Fang Chen, Joseph A. Fraietta, Carl H. June, Zhongwei Xu, J. Joseph Melenhorst, Simon F. Lacey

Engineering 2019, Volume 5, Issue 1,   Pages 140-149 doi: 10.1016/j.eng.2018.11.010

Abstract: The process of developing CART19 essentially follows the conventional “one gene, one drug, one” it is useful to use CART19 as an example to examine the similarities and differences in its development, compared with that of a conventional drug.We believe that the success of CART19 will lead to the development of other engineered T cell therapies

Keywords： Engineered T cell therapies     Chimeric antigen receptor     Drug development process     Biomarkers     CAR19    

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Development Strategy of Integrative Pharmacy

Zhang Yong, Zhao Yixiu, Yang Baofeng

Strategic Study of CAE 2021, Volume 23, Issue 1,   Pages 185-192 doi: 10.15302/J-SSCAE-2021.01.022

Abstract: style="font-size:9.0000pt">drugresearch and development, innovation of traditional Chinese medicine, clinical practice of drugs, constructionTo promote the new drug research and development based on integrative pharmacy, the design idea of integrativedrugs should be innovated, a drug evaluation system that adapts to integrative pharmacy should be developed,and a new drug development system should be established for integrative drugs.

Keywords： integrative pharmacy     integrative drugs     new drug development     drug evaluation     clinical medication guidance    

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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract:

Identification of the driver mutations in cancer has resulted in the development of a new categoryWhile most cancer therapies are given in combinations that are designed to avoid drug resistance, wediscuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon developmentof drug resistance.We discuss the development of sequential drug therapies in which the first therapy is not given with

Keywords： cancer     drug resistance     genetic screens     senescence     targeted therapy    

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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 116-122 doi: 10.1007/s11705-013-1310-0

Abstract: acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drugIn addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium.This may be attributed to Fickian diffusion since the drug and the medium in which it was released have

Keywords： psyllium     acetyl salicylic acid     in-vitro drug release     swelling     biodegradation    

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Protein microspheres for pulmonary drug delivery

Yongda SUN,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 82-86 doi: 10.1007/s11705-009-0307-1

Abstract: supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonary drugThis technique, based on the anti-solvent process, has incorporated advanced engineering design featuresto enable improved control of the particle formation process.Human recombinant insulin (HRI) was used as a model compound to evaluate the efficiency of this SCF processleading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug

Keywords： advanced engineering     improved     pressure     aqueous     technique    

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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2,   Pages 225-232 doi: 10.1007/s11705-014-1429-7

Abstract: These polymers are selected based on their importance and broad scope of application in FDA-approved drugGlyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed

Keywords： controlled release     drug delivery     semi-solids     polymer     excipient    

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Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 3,   Pages 246-252 doi: 10.1007/s11705-012-1299-9

Abstract: The properties of the different kinds of spheres as drug delivery carriers were evaluated.Ibuprofen (IBU) was chosen as the model drug to load into the HA samples.The HA hollow spheres exhibited a higher drug loading capacity and more favorable release propertiesthan the HA solid spheres and thus are very promising for controlled drug release applications.

Keywords： hydroxyapatite     hollow spheres     synthesis     drug release    

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Process development for green part printing using binder jetting additive manufacturing

Hadi MIYANAJI, Morgan ORTH, Junaid Muhammad AKBAR, Li YANG

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 4,   Pages 504-512 doi: 10.1007/s11465-018-0508-8

Abstract:

Originally developed decades ago, the binder jetting additive manufacturing (BJ-AM) process possessesIn this work, the process design considerations for BJ-AM in green part fabrication were discussed inVarious process factors, including binder saturation, in-process drying, powder spreading, powder feedstockIn addition, during the process development, the balanced combination between the saturation level andin-process drying is of critical importance in the quality control of the green parts.

Keywords： binder jetting     additive manufacturing     green part     process optimization     process development    

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Toward the development of process plans with reduced environmental impacts

Fu ZHAO, Vance R. MURRAY, Karthik RAMANI, John W. SUTHERLAND

Frontiers of Mechanical Engineering 2012, Volume 7, Issue 3,   Pages 231-246 doi: 10.1007/s11465-012-0334-3

Abstract:

Manufacturing process planning serves as a pivotal link between design and manufacturing.Process planning decisions play a critical role in determining the cost and environmental impacts associatedPast efforts to address environmental issues during process planning are briefly reviewed and potentialA proposed method is presented for environmentally conscious process planning.The method begins with an existing process plan, and then identifies impactful process steps, and associated

Keywords： process planning     life cycle assessment (LCA)     sustainable manufacturing     prosthetic hip shell    

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Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial

Feng Qi, Jie Wu, Hao Li, Guanghui Ma

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1,   Pages 14-27 doi: 10.1007/s11705-018-1729-4

Abstract: L-lactic-co-glycolic acid) (PLGA)/poly(lactic acid) (PLA) microspheres/nanoparticles are one of the most successful drugThere have been 15 products available on the US market, but the system still has many problems during developmentand manufacturing, such as wide size distribution, drug stability issues, and so on.Furthermore, the relevant FDA guidance on the DDS is still incomplete, especially for abbreviated new drugThe review provides an overview on the development of the system in pharmaceutical industry.

Keywords： PLGA     microspheres     drug delivery system     stability     manufacturing    

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Prevalence of antifolate drug resistance markers in in China

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 83-92 doi: 10.1007/s11684-021-0894-x

Abstract: dhps) genes of Plasmodium vivax and antifolate resistance-associated genes were used for drugvivax parasites were different across China and molecular markers could be used to rapidly monitor drugResults provided evidence for updating national drug policy and treatment guidelines.

Keywords： drug resistance     antifolates     molecular markers     Plasmodium vivax     China    

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Clinical analysis of 275 cases of acute drug-induced liver disease

LI Lei, JIANG Wei, WANG Jiyao

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 58-61 doi: 10.1007/s11684-007-0012-8

Abstract: causative drugs, clinical manifestation and pathological characteristics of the patients with acute drug-inducedliver disease, from January 2000 to December 2005, 275 cases diagnosed as acute drug-induced liver diseasesEach was determined by drug history, clinical symptoms and signs, laboratory tests and therapeutic effectsThe proportion of acute drug-induced liver disease among all of the acute liver injuries was annuallyThe clinicians should pay attention to the prevention, diagnosis and therapy of drug-induced liver disease
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Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery

Zhijian CHEN, Wei LI,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 1-1 doi: 10.1007/s11705-009-0306-2

Abstract:
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Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 4,   Pages 483-489 doi: 10.1007/s11705-022-2227-2

Abstract: advantage of taking place in biological environments without interfering with an innate biochemical process

Keywords： bioorthogonal reaction     cancer therapy     metabolic glycoengineering     bioorthogonal catalytic patch    

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Title Author Date Type Operation

Development of a multi-component drug from turmeric using central composite design

Xiaohang ZHANG,Shengnan HAN,Yan LI,Jianlan JIANG

Journal Article

Engineered T Cell Therapies from a Drug Development Viewpoint

Fang Chen, Joseph A. Fraietta, Carl H. June, Zhongwei Xu, J. Joseph Melenhorst, Simon F. Lacey

Journal Article

Development Strategy of Integrative Pharmacy

Zhang Yong, Zhao Yixiu, Yang Baofeng

Journal Article

Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Journal Article

Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Journal Article

Protein microspheres for pulmonary drug delivery

Yongda SUN,

Journal Article

Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Journal Article

Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

Journal Article

Process development for green part printing using binder jetting additive manufacturing

Hadi MIYANAJI, Morgan ORTH, Junaid Muhammad AKBAR, Li YANG

Journal Article

Toward the development of process plans with reduced environmental impacts

Fu ZHAO, Vance R. MURRAY, Karthik RAMANI, John W. SUTHERLAND

Journal Article

Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial

Feng Qi, Jie Wu, Hao Li, Guanghui Ma

Journal Article

Prevalence of antifolate drug resistance markers in in China

Journal Article

Clinical analysis of 275 cases of acute drug-induced liver disease

LI Lei, JIANG Wei, WANG Jiyao

Journal Article

Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery

Zhijian CHEN, Wei LI,

Journal Article

Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

Journal Article